Cardiovascular risk stratification in familial hypercholesterolaemia
نویسندگان
چکیده
منابع مشابه
Cardiovascular risk stratification in familial hypercholesterolaemia
Familial hypercholesterolaemia (FH) is a common autosomal-dominant disorder in most European countries. Patients with FH are characterised by a raised level of low-density lipoprotein cholesterol and a high risk of premature coronary heart disease (CHD). Currently there is no consensus regarding the clinical utility to predict future coronary events or testing for the presence of subclinical at...
متن کاملLipoprotein(a) determination and risk of cardiovascular disease in South African patients with familial hypercholesterolaemia.
OBJECTIVE A raised plasma level of lipoprotein(a) (Lp(a)) is an established genetic risk factor for coronary heart disease (CHD), particularly in patients with concomitant elevation of low-density lipoprotein (LDL) cholesterol. The current study focused on the comparison of two commercially available Lp(a) assay kits to determine whether differences observed in measured Lp(a) levels could be de...
متن کاملFamilial hypercholesterolaemia in Portugal.
Familial hypercholesterolaemia (FH) is characterised clinically by an increased level of circulating LDL cholesterol that leads to lipid accumulation in tendons and arteries, premature atherosclerosis and increased risk of coronary heart disease (CHD). Although Portugal should have about 20,000 cases, this disease is severely under-diagnosed in our country, this being the first presentation of ...
متن کاملCARDIOVASCULAR MEDICINE Established and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia
Objectives: To assess the clinical and biochemical factors associated with inter-individual variation in susceptibility to coronary artery disease (CAD) in treated heterozygous familial hypercholesterolaemia. Design: A cross sectional study was conducted of 410 patients recruited from six lipid clinics in the UK. Results: CAD was documented in 104 of the 211 men and in 55 of the 199 women with ...
متن کاملComplement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.
AIMS Activation of the complement system seems an important link between inflammation and atherogenesis. The Y402H polymorphism of complement factor H (CFH) has been associated with cardiovascular events, but results are conflicting and possibly modified by age of onset of cardiovascular disease (CVD). METHODS AND RESULTS We determined whether or not the Y402H polymorphism influenced CVD risk...
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ژورنال
عنوان ژورنال: Heart
سال: 2016
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2015-308845